Bait ORF Bait gene name Bait description Rows with this bait as bait Rows with this bait as prey Prey ORF Prey gene name Prey description Rows with this prey as prey Rows with this prey as bait Literature on bait (YPD) Literature on prey (YPD) Literature shared by bait and prey Literature sharing score CuraGen (0 or 1) S. Fields (0 or 1) Association (0 or 1,YPD) Complex (0 or 1,YPD) Synthetic lethality (0 or 1,YPD) Co-induced by (YPD) Co-repressed by (YPD) Not affected by(YPD) Interologs Expression similarity (BRITE) Alternative path with 1 intervening protein (YPD) Alternative path with 2 intervening proteins (YPD) IST hit IST hit in the opposite bait/prey orientation

YAL025C

MAK16

Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus

1 hit
Search Bait by Bait ORF

0 hit
Search Prey by Bait ORF

YJR044C

VPS55

Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)

1 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

15

5

2

2

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599e28>

YAL025C

 

MAK16

 

Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus

 

1 hit
Search Bait by Bait ORF

 

0 hit
Search Prey by Bait ORF

 

YJR044C

 

VPS55

 

Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)

 

1 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

15

 

5

 

2

 

2

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL026C

DRS2

Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease

1 hit
Search Bait by Bait ORF

0 hit
Search Prey by Bait ORF

YPL146C

NOP53

Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired

1 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

22

4

2

2

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599dec>

YAL026C

 

DRS2

 

Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease

 

1 hit
Search Bait by Bait ORF

 

0 hit
Search Prey by Bait ORF

 

YPL146C

 

NOP53

 

Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired

 

1 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

22

 

4

 

2

 

2

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL032C

PRP45

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

4 hit
Search Bait by Bait ORF

3 hit
Search Prey by Bait ORF

YDR416W

SYF1

Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein

9 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

6

7

4

7

0

0

0

0

0

-

-

-

-

-

0

0

2

-

Show
#<YipdFullUpdated:0xb7599dc4>

YAL032C

 

PRP45

 

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

 

4 hit
Search Bait by Bait ORF

 

3 hit
Search Prey by Bait ORF

 

YDR416W

 

SYF1

 

Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein

 

9 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

6

 

7

 

4

 

7

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

2

 

-

 

YAL032C

PRP45

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

4 hit
Search Bait by Bait ORF

3 hit
Search Prey by Bait ORF

YLR345W

-

Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene

4 hit
Search Prey by Prey ORF

2 hit
Search Bait by Prey ORF

6

6

4

7

1

0

0

0

0

-

-

-

-

-

0

0

2

-

Show
#<YipdFullUpdated:0xb7599d9c>

YAL032C

 

PRP45

 

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

 

4 hit
Search Bait by Bait ORF

 

3 hit
Search Prey by Bait ORF

 

YLR345W

 

-

 

Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene

 

4 hit
Search Prey by Prey ORF

 

2 hit
Search Bait by Prey ORF

 

6

 

6

 

4

 

7

 

1

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

2

 

-

 

YAL032C

PRP45

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

4 hit
Search Bait by Bait ORF

3 hit
Search Prey by Bait ORF

YLR423C

ATG17

Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity

50 hit
Search Prey by Prey ORF

17 hit
Search Bait by Prey ORF

6

6

4

7

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599d74>

YAL032C

 

PRP45

 

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

 

4 hit
Search Bait by Bait ORF

 

3 hit
Search Prey by Bait ORF

 

YLR423C

 

ATG17

 

Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity

 

50 hit
Search Prey by Prey ORF

 

17 hit
Search Bait by Prey ORF

 

6

 

6

 

4

 

7

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL032C

PRP45

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

4 hit
Search Bait by Bait ORF

3 hit
Search Prey by Bait ORF

YOR036W

PEP12

Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin

5 hit
Search Prey by Prey ORF

3 hit
Search Bait by Prey ORF

6

59

4

7

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599d4c>

YAL032C

 

PRP45

 

Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

 

4 hit
Search Bait by Bait ORF

 

3 hit
Search Prey by Bait ORF

 

YOR036W

 

PEP12

 

Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin

 

5 hit
Search Prey by Prey ORF

 

3 hit
Search Bait by Prey ORF

 

6

 

59

 

4

 

7

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL033W

POP5

Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends

1 hit
Search Bait by Bait ORF

0 hit
Search Prey by Bait ORF

YJR115W

-

Putative protein of unknown function

1 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

21

5

3

4

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599d24>

YAL033W

 

POP5

 

Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends

 

1 hit
Search Bait by Bait ORF

 

0 hit
Search Prey by Bait ORF

 

YJR115W

 

-

 

Putative protein of unknown function

 

1 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

21

 

5

 

3

 

4

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL035W

FUN12

GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2

1 hit
Search Bait by Bait ORF

0 hit
Search Prey by Bait ORF

YLR241W

-

Putative protein of unknown function, may be involved in detoxification

1 hit
Search Prey by Prey ORF

2 hit
Search Bait by Prey ORF

13

5

3

4

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599cfc>

YAL035W

 

FUN12

 

GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2

 

1 hit
Search Bait by Bait ORF

 

0 hit
Search Prey by Bait ORF

 

YLR241W

 

-

 

Putative protein of unknown function, may be involved in detoxification

 

1 hit
Search Prey by Prey ORF

 

2 hit
Search Bait by Prey ORF

 

13

 

5

 

3

 

4

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL036C

RBG1

Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid

2 hit
Search Bait by Bait ORF

2 hit
Search Prey by Bait ORF

YDL065C

PEX19

Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane

11 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

6

11

3

5

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599cd4>

YAL036C

 

RBG1

 

Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid

 

2 hit
Search Bait by Bait ORF

 

2 hit
Search Prey by Bait ORF

 

YDL065C

 

PEX19

 

Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane

 

11 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

6

 

11

 

3

 

5

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL036C

RBG1

Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid

2 hit
Search Bait by Bait ORF

2 hit
Search Prey by Bait ORF

YNR022C

MRPL50

Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation

1 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

6

4

3

5

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599cac>

YAL036C

 

RBG1

 

Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid

 

2 hit
Search Bait by Bait ORF

 

2 hit
Search Prey by Bait ORF

 

YNR022C

 

MRPL50

 

Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation

 

1 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

6

 

4

 

3

 

5

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL042W

ERV46

Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport

1 hit
Search Bait by Bait ORF

0 hit
Search Prey by Bait ORF

YDL239C

ADY3

Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p

5 hit
Search Prey by Prey ORF

25 hit
Search Bait by Prey ORF

5

4

3

4

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599c84>

YAL042W

 

ERV46

 

Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport

 

1 hit
Search Bait by Bait ORF

 

0 hit
Search Prey by Bait ORF

 

YDL239C

 

ADY3

 

Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p

 

5 hit
Search Prey by Prey ORF

 

25 hit
Search Bait by Prey ORF

 

5

 

4

 

3

 

4

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAL064W

-

Protein of unknown function; may interact with ribosomes, based on co-purification experiments

1 hit
Search Bait by Bait ORF

2 hit
Search Prey by Bait ORF

YKR011C

-

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus

1 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

2

-

-

-

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599c5c>

YAL064W

 

-

 

Protein of unknown function; may interact with ribosomes, based on co-purification experiments

 

1 hit
Search Bait by Bait ORF

 

2 hit
Search Prey by Bait ORF

 

YKR011C

 

-

 

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus

 

1 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

2

 

-

 

-

 

-

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAR007C

RFA1

Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination

1 hit
Search Bait by Bait ORF

1 hit
Search Prey by Bait ORF

YJL173C

RFA3

Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination

3 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

67

41

37

274

0

0

0

1

0

MluI-Binding Factor,YDL056W,YLR182W,cell cycle G1/S,cell cycle late G1

-

-

-

-

1

1

1

-

Show
#<YipdFullUpdated:0xb7599c34>

YAR007C

 

RFA1

 

Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination

 

1 hit
Search Bait by Bait ORF

 

1 hit
Search Prey by Bait ORF

 

YJL173C

 

RFA3

 

Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination

 

3 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

67

 

41

 

37

 

274

 

0

 

0

 

0

 

1

 

0

 

MluI-Binding Factor,YDL056W,YLR182W,cell cycle G1/S,cell cycle late G1

 

-

 

-

 

-

 

-

 

1

 

1

 

1

 

-

 

YAR008W

SEN34

Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease

1 hit
Search Bait by Bait ORF

1 hit
Search Prey by Bait ORF

YBL051C

PIN4

Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage

2 hit
Search Prey by Prey ORF

0 hit
Search Bait by Prey ORF

13

5

3

4

0

0

0

0

0

-

-

-

-

-

0

0

1

-

Show
#<YipdFullUpdated:0xb7599c0c>

YAR008W

 

SEN34

 

Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease

 

1 hit
Search Bait by Bait ORF

 

1 hit
Search Prey by Bait ORF

 

YBL051C

 

PIN4

 

Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage

 

2 hit
Search Prey by Prey ORF

 

0 hit
Search Bait by Prey ORF

 

13

 

5

 

3

 

4

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

1

 

-

 

YAR018C

KIN3

Nonessential protein kinase with unknown cellular role

1 hit
Search Bait by Bait ORF

3 hit
Search Prey by Bait ORF

YAR018C

KIN3

Nonessential protein kinase with unknown cellular role

3 hit
Search Prey by Prey ORF

1 hit
Search Bait by Prey ORF

15

15

-

-

0

0

0

0

0

-

-

-

9

-

0

0

1

-1

Show
#<YipdFullUpdated:0xb7599be4>

YAR018C

 

KIN3

 

Nonessential protein kinase with unknown cellular role

 

1 hit
Search Bait by Bait ORF

 

3 hit
Search Prey by Bait ORF

 

YAR018C

 

KIN3

 

Nonessential protein kinase with unknown cellular role

 

3 hit
Search Prey by Prey ORF

 

1 hit
Search Bait by Prey ORF

 

15

 

15

 

-

 

-

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

9

 

-

 

0

 

0

 

1

 

-1