Bait ORF Bait gene name Bait description Rows with this bait as bait Rows with this bait as prey Prey ORF Prey gene name Prey description Rows with this prey as prey Rows with this prey as bait Literature on bait (YPD) Literature on prey (YPD) Literature shared by bait and prey Literature sharing score CuraGen (0 or 1) S. Fields (0 or 1) Association (0 or 1,YPD) Complex (0 or 1,YPD) Synthetic lethality (0 or 1,YPD) Co-induced by (YPD) Co-repressed by (YPD) Not affected by(YPD) Interologs Expression similarity (BRITE) Alternative path with 1 intervening protein (YPD) Alternative path with 2 intervening proteins (YPD) IST hit IST hit in the opposite bait/prey orientation

YAR033W

MST28

Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles

Rows with this bait as bait (1)

Rows with this bait as prey (1)

YAR033W

MST28

Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles

Rows with this prey as prey (1)

Rows with this prey as bait (1)

6

6

-

-

0

0

0

0

0

-

-

-

-

-

0

0

4

-1

Show
#<YipdCoreUpdated:0xb760ecdc>

YAR033W

 

MST28

 

Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (1)

 

YAR033W

 

MST28

 

Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles

 

Rows with this prey as prey (1)

 

Rows with this prey as bait (1)

 

6

 

6

 

-

 

-

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

4

 

-1

 

YBL006C

LDB7

Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions

Rows with this bait as bait (1)

Rows with this bait as prey (0)

YDR489W

SLD5

Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

Rows with this prey as prey (5)

Rows with this prey as bait (0)

3

3

2

2

0

0

0

0

0

-

-

-

-

-

0

0

7

-

Show
#<YipdCoreUpdated:0xb760eca0>

YBL006C

 

LDB7

 

Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (0)

 

YDR489W

 

SLD5

 

Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

 

Rows with this prey as prey (5)

 

Rows with this prey as bait (0)

 

3

 

3

 

2

 

2

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

7

 

-

 

YBL016W

FUS3

Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation

Rows with this bait as bait (2)

Rows with this bait as prey (0)

YDR480W

DIG2

Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription

Rows with this prey as prey (1)

Rows with this prey as bait (0)

134

11

8

47

0

0

1

0

0

-

-

-

-

-

0

7

8

-

Show
#<YipdCoreUpdated:0xb760ec78>

YBL016W

 

FUS3

 

Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation

 

Rows with this bait as bait (2)

 

Rows with this bait as prey (0)

 

YDR480W

 

DIG2

 

Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription

 

Rows with this prey as prey (1)

 

Rows with this prey as bait (0)

 

134

 

11

 

8

 

47

 

0

 

0

 

1

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

7

 

8

 

-

 

YBL016W

FUS3

Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation

Rows with this bait as bait (2)

Rows with this bait as prey (0)

YPL049C

DIG1

Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription

Rows with this prey as prey (1)

Rows with this prey as bait (0)

134

12

10

55

0

0

1

0

0

-

-

-

-

-

0

7

10

-

Show
#<YipdCoreUpdated:0xb760ec50>

YBL016W

 

FUS3

 

Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation

 

Rows with this bait as bait (2)

 

Rows with this bait as prey (0)

 

YPL049C

 

DIG1

 

Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription

 

Rows with this prey as prey (1)

 

Rows with this prey as bait (0)

 

134

 

12

 

10

 

55

 

0

 

0

 

1

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

7

 

10

 

-

 

YBL026W

LSM2

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA

Rows with this bait as bait (1)

Rows with this bait as prey (0)

YCR077C

PAT1

Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p

Rows with this prey as prey (4)

Rows with this prey as bait (0)

18

12

4

17

0

0

0

1

0

-

-

-

-

-

1

6

3

-

Show
#<YipdCoreUpdated:0xb760ec28>

YBL026W

 

LSM2

 

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (0)

 

YCR077C

 

PAT1

 

Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p

 

Rows with this prey as prey (4)

 

Rows with this prey as bait (0)

 

18

 

12

 

4

 

17

 

0

 

0

 

0

 

1

 

0

 

-

 

-

 

-

 

-

 

-

 

1

 

6

 

3

 

-

 

YBL033C

RIB1

GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway

Rows with this bait as bait (2)

Rows with this bait as prey (0)

YNL105W

RRT16

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription

Rows with this prey as prey (1)

Rows with this prey as bait (0)

10

2

2

2

0

0

0

0

0

-

-

-

-

-

0

0

4

-

Show
#<YipdCoreUpdated:0xb760ec00>

YBL033C

 

RIB1

 

GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway

 

Rows with this bait as bait (2)

 

Rows with this bait as prey (0)

 

YNL105W

 

RRT16

 

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription

 

Rows with this prey as prey (1)

 

Rows with this prey as bait (0)

 

10

 

2

 

2

 

2

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

4

 

-

 

YBL033C

RIB1

GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway

Rows with this bait as bait (2)

Rows with this bait as prey (0)

YPR172W

-

Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance

Rows with this prey as prey (1)

Rows with this prey as bait (0)

10

3

3

4

0

0

0

0

0

-

-

-

-

-

0

0

4

-

Show
#<YipdCoreUpdated:0xb760ebd8>

YBL033C

 

RIB1

 

GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway

 

Rows with this bait as bait (2)

 

Rows with this bait as prey (0)

 

YPR172W

 

-

 

Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance

 

Rows with this prey as prey (1)

 

Rows with this prey as bait (0)

 

10

 

3

 

3

 

4

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

4

 

-

 

YBL039C

URA7

Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis

Rows with this bait as bait (1)

Rows with this bait as prey (1)

YJR103W

URA8

Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis

Rows with this prey as prey (2)

Rows with this prey as bait (2)

24

11

10

58

0

0

0

0

1

-

stationary phase

-

-

-

0

0

4

9

Show
#<YipdCoreUpdated:0xb760ebb0>

YBL039C

 

URA7

 

Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (1)

 

YJR103W

 

URA8

 

Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis

 

Rows with this prey as prey (2)

 

Rows with this prey as bait (2)

 

24

 

11

 

10

 

58

 

0

 

0

 

0

 

0

 

1

 

-

 

stationary phase

 

-

 

-

 

-

 

0

 

0

 

4

 

9

 

YBL045C

COR1

Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain

Rows with this bait as bait (1)

Rows with this bait as prey (1)

YPR191W

QCR2

Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme

Rows with this prey as prey (2)

Rows with this prey as bait (1)

27

23

14

89

0

0

1

1

0

heme

-

-

2

-

7

47

11

3

Show
#<YipdCoreUpdated:0xb760eb88>

YBL045C

 

COR1

 

Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (1)

 

YPR191W

 

QCR2

 

Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme

 

Rows with this prey as prey (2)

 

Rows with this prey as bait (1)

 

27

 

23

 

14

 

89

 

0

 

0

 

1

 

1

 

0

 

heme

 

-

 

-

 

2

 

-

 

7

 

47

 

11

 

3

 

YBL056W

PTC3

Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation

Rows with this bait as bait (1)

Rows with this bait as prey (0)

YDR071C

PAA1

Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication

Rows with this prey as prey (1)

Rows with this prey as bait (0)

13

3

0

0

0

0

0

0

0

-

-

-

-

-

0

0

4

-

Show
#<YipdCoreUpdated:0xb760eb60>

YBL056W

 

PTC3

 

Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (0)

 

YDR071C

 

PAA1

 

Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication

 

Rows with this prey as prey (1)

 

Rows with this prey as bait (0)

 

13

 

3

 

0

 

0

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

4

 

-

 

YBL068W

PRS4

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes

Rows with this bait as bait (1)

Rows with this bait as prey (0)

YOL061W

PRS5

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes

Rows with this prey as prey (2)

Rows with this prey as bait (1)

9

11

8

39

0

0

1

1

0

-

-

-

-

-

0

0

4

-

Show
#<YipdCoreUpdated:0xb760eb38>

YBL068W

 

PRS4

 

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (0)

 

YOL061W

 

PRS5

 

5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes

 

Rows with this prey as prey (2)

 

Rows with this prey as bait (1)

 

9

 

11

 

8

 

39

 

0

 

0

 

1

 

1

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

4

 

-

 

YBR059C

AKL1

Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization

Rows with this bait as bait (1)

Rows with this bait as prey (3)

YBR059C

AKL1

Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization

Rows with this prey as prey (3)

Rows with this prey as bait (1)

8

8

-

-

0

0

0

0

0

-

-

-

11

-

0

0

4

-1

Show
#<YipdCoreUpdated:0xb760eb10>

YBR059C

 

AKL1

 

Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (3)

 

YBR059C

 

AKL1

 

Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization

 

Rows with this prey as prey (3)

 

Rows with this prey as bait (1)

 

8

 

8

 

-

 

-

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

11

 

-

 

0

 

0

 

4

 

-1

 

YBR077C

SLM4

Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4

Rows with this bait as bait (1)

Rows with this bait as prey (1)

YKR007W

MEH1

Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification

Rows with this prey as prey (1)

Rows with this prey as bait (2)

3

6

1

3

1

0

0

0

0

-

-

-

-

-

0

0

12

6

Show
#<YipdCoreUpdated:0xb760eae8>

YBR077C

 

SLM4

 

Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (1)

 

YKR007W

 

MEH1

 

Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification

 

Rows with this prey as prey (1)

 

Rows with this prey as bait (2)

 

3

 

6

 

1

 

3

 

1

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

12

 

6

 

YBR094W

PBY1

Putative tubulin tyrosine ligase associated with P-bodies

Rows with this bait as bait (1)

Rows with this bait as prey (0)

YOL149W

DCP1

Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p

Rows with this prey as prey (6)

Rows with this prey as bait (1)

5

31

3

5

0

0

0

0

0

-

-

-

-

-

1

4

9

-

Show
#<YipdCoreUpdated:0xb760eac0>

YBR094W

 

PBY1

 

Putative tubulin tyrosine ligase associated with P-bodies

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (0)

 

YOL149W

 

DCP1

 

Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p

 

Rows with this prey as prey (6)

 

Rows with this prey as bait (1)

 

5

 

31

 

3

 

5

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

1

 

4

 

9

 

-

 

YBR103W

SIF2

WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus

Rows with this bait as bait (1)

Rows with this bait as prey (1)

YJR141W

-

Essential protein of unknown function

Rows with this prey as prey (3)

Rows with this prey as bait (1)

8

3

3

7

0

0

0

0

0

-

-

-

-

-

0

0

3

3

Show
#<YipdCoreUpdated:0xb760ea98>

YBR103W

 

SIF2

 

WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus

 

Rows with this bait as bait (1)

 

Rows with this bait as prey (1)

 

YJR141W

 

-

 

Essential protein of unknown function

 

Rows with this prey as prey (3)

 

Rows with this prey as bait (1)

 

8

 

3

 

3

 

7

 

0

 

0

 

0

 

0

 

0

 

-

 

-

 

-

 

-

 

-

 

0

 

0

 

3

 

3