hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /bio/db/ideas/pfam/Pfam_ls Sequence file: query/000002.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: 1.m00608 Accession: [none] Description: protein kinase, putative 1.t00011 AAFB01000002 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 257.1 3.8e-74 2 Pkinase_Tyr Protein tyrosine kinase 29.3 3.4e-14 1 DUF1912 Domain of unknown function (DUF1912) -27.2 4.1 1 DUF1694 Protein of unknown function (DUF1694) -76.0 6.5 1 DUF1703 Protein of unknown function (DUF1703) -371.7 9.3 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Pkinase 1/2 15 280 .. 1 287 [] 55.8 1.5e-13 DUF1694 1/1 50 139 .. 1 129 [] -76.0 6.5 DUF1703 1/1 50 502 .. 1 612 [] -371.7 9.3 DUF1912 1/1 223 313 .. 1 84 [] -27.2 4.1 Pkinase_Tyr 1/1 297 561 .. 1 272 [] 29.3 3.4e-14 Pkinase 2/2 297 561 .. 1 287 [] 201.3 2.3e-57 Alignments of top-scoring domains: Pkinase: domain 1 of 2, from 15 to 280: score 55.8, E = 1.5e-13 *->yelleklGsGsfGtVykakhkgtgk.............iVAvKiikk +++ l yk ++ k +++++ ++++ +iVA+K ik+ 1.m00608 15 FTIQDEL--------YKDSKIEIHKatersglrhrqvrIVAIKMIKV 53 rkekskkdktarrlsEiq..ilkrLsHpNIvrlidvfed....kdhlylV +++k +++k++ E++++++ ++ p++++++ +f+++ +++ +++++ 1.m00608 54 DENKIEENKRR----EVYskYMETIDNPHVLQYFNSFYTtirgSLEYWII 99 lEycegGLrvldLfdylsetrrkgpllfsedeakkialQilrgleYLHs. +Eyc + +y + ++ + + d+ +++ i+ gleY++++ 1.m00608 100 MEYCSFK----SIDEYWK---SNAII--QQDQNLFFISDIAIGLEYIYEt 140 ngiiHRDLKPeNILld.nngvvdaflKiaDFGlAkklst.ssslttfvGT + H L P NILl+++ + +++K++ FGl+ ++ ++ ++ + 1.m00608 141 LNHQHLHLYPCNILLSrDPASIFPKVKLSNFGLCDQF-EqTIPNELELCD 189 pwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFs.gevqdsldql +Y+APE l+ + +k+DvWS+G +++ ll G++PF + d + 1.m00608 190 VDYAAPEYLN--WYSHSKSDVWSFGMLIFKLLVGRLPFElMQ----MDSF 233 qlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPsk i ++++ ++ +e a+dL++k+L++DP + 1.m00608 234 SAIPAQVFIDVSSFIQ----------------NEMACDLLSKMLQYDPDE 267 RltaeeilqHPwf<-* R++ +e+l HP++ 1.m00608 268 RISMQEVLTHPFI 280 DUF1694: domain 1 of 1, from 50 to 139: score -76.0, E = 6.5 *->MtekdvDlddrLqegmyGtpllnPDEQr....rYLGTFrERVelalT M + vD ++++ + +r+ ++Y+ 1.m00608 50 MIK--VD-----------ENKIEENKRRevysKYM------------ 71 iaealrqnylkeLeseLkkLqlkhpnlqLLlNGkLdydilsqYiKLAnqy ++++++ +l +++s + + G+L+y i++ Y ++ + 1.m00608 72 -ETIDNPHVLQYFNSFYTT-----------IRGSLEYWIIMEY---CSFK 106 gipFTIvndqeyetnpDpiGlvLaadhAiNkeeIDi<-* +i+ +++ ++ + l + +d+Ai e I+ 1.m00608 107 SIDEYWKSNAIIQQ---DQNLFFISDIAIGLEYIYE 139 DUF1703: domain 1 of 1, from 50 to 502: score -371.7, E = 9.3 *->MdkimKrIPiGisnFeeireenY...YYVDKTeYIyrLektgsyykF M+k e +een ++++Y +Y + +++ + 1.m00608 50 MIKVD----------ENKIEENKrreVY---SKYMETIDNPHVLQ-Y 82 liRPRRFGKSLllStLeaYfDikkKdkFeeLFggLyIekleTFKeqnkYp + +++ ++le+ 1.m00608 83 F---------------NSFYTTIR-------------GSLEY------WI 98 vlhl.dfsaivKadneeeLeqsfnsyccgl..lddFryllddLdkfDlee ++ + +f++i+ + ++ q + +++ + + y+ ++L+ l 1.m00608 99 IMEYcSFKSIDEYWKSNAIIQQDQNLFFISdiAIGLEYIYETLNHQHLHL 148 y.eklygkefieldeeseedpgerLlni.ikraaektgkkVvlLIDEYDN y+ +++ + d +s p+ L+n+++++ +e+t + L D 1.m00608 149 YpCNILLS----RDPAS-IFPKVKLSNFgLCDQFEQTIPNELELCD---- 189 FTnplLtaygneeYqkithgsgFlRtFykvlKkadge.gyirriFlTGVs ++y +eY + + K++ g++ + +l G + 1.m00608 190 ------VDYAAPEYLNWY----------SHSKSDVWSfGMLIFKLLVGRL 223 pV..tkddlfSGlNilrnisIldpnFnamcGfteeE.....vrtmLkyyk p++ +++d fS I F++ f ++E + +++mL+y+ 1.m00608 224 PFelMQMDSFSA--------IPAQVFIDVSSFIQNEmacdlLSKMLQYDP 265 eqlalkqditideiitelKpwYDGYhFaesslkDPsmYNPdslLyf..la +++ +q + + i++ K +Y+ + ++ ++ ++++l+ 1.m00608 266 DERISMQEVLTHPFIQMCK----NYKYGTQGKRE----------NYkpLK 301 kyiangkfpdywvDtntrTdlnklrkLIrLdksdgdlkevlqei..aeag + + +g f+ + +nt d++ + +ke+ q+i++ + + 1.m00608 302 Q-LDHGQFGQVFLAENT-------------DHTQFAIKEISQRIdsLIRE 337 elPYNttnlstsFnadeltntkenfksLLyYsGyLTIkGYdrefglyiLg l + n+ e + +e s ++ I G + ++g y+ 1.m00608 338 AS---CMRLCKHPNLVEYKDFFEWNHSMIA-----EIRGEQSPEGKYV-- 377 iPNkeVRegymkyllprYqnsgilaiesnfyvdlfnrmafdGdidpller yl +Y n g ++ ++ ++ ++ + 1.m00608 378 ------------YLVMEYCNAG-------NLEIYIKNKPTPLSNEEISYF 408 lqeafladssvrdlikigEkhyq......gfflaylsRYLngyYivkp.E l+e + + + + ++k + ++++ ++ +++l s + y ++k+ 1.m00608 409 LGE-ICSGLWYLHFNK---RLIHrdlkpaNLLLKSSS---SKYPLLKIaD 451 yetnkGRaDfvLkgiPdlqyydtdkfsYviEfKYakesdsdkelektaeE y ++G +D ++k + + ++ E 1.m00608 452 YGFSRG-IDGMMK---------SM-------------------VGTPLYE 472 AleQIneKgYAasekVkfqlgdtkLkkIginFcgkklvigeE<-* A e + Y+a +l +++ + ++ +E 1.m00608 473 APEIRKNQPYTAK----ADLYSLGVILYYMA--------TKE 502 DUF1912: domain 1 of 1, from 223 to 313: score -27.2, E = 4.1 *->MsYEqeFLKdFeeWVktQvqi.......nelAmkaskkvaeEDgder + +E + F + + Qv i+ ++ +ne+A + k ++ D der 1.m00608 223 LPFELMQMDSFSA-IPAQVFIdvssfiqNEMACDLLSKMLQYDPDER 268 ..AkdAaiR.YESkLDAYqF.LlGKFeNYkngKgFHDlPDgLFGerhY<- + ++ +++ Y+++ +GK eNYk K l g FG+ 1.m00608 269 isMQEVLTHpFIQMCKNYKYgTQGKRENYKPLKQ---LDHGQFGQVFL 313 * 1.m00608 - - Pkinase_Tyr: domain 1 of 1, from 297 to 561: score 29.3, E = 3.4e-14 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie k +k+L +G+FG V++++ + ++++ A+K + s++ 1.m00608 297 YKPLKQLDHGQFGQVFLAENT-----DHTQFAIKEI-----SQR--- 330 redFlrEAsiMkklGdHpNiVrLlGvct...............kegePgg +++++rEAs M+ +HpN+V + + +++ + +++++++ g+ 1.m00608 331 IDSLIREASCMRLC-KHPNLVEYKDFFEwnhsmiaeirgeqspE-GKY-- 376 pglyiVtEymegGdLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesk +y+V+Ey+ G+L + +++ + pL+ +++ f +i++G+ YL+ + 1.m00608 377 --VYLVMEYCNAGNLEIYIKNK--PTPLSNEEISYFLGEICSGLWYLHFN 422 n.fvHRDLAARNcLVse...nl.vVKIsDFGLaRdiysddyYvrkrgggk ++++HRDL N L+++++++ + KI+D G +R i d+ ++ g++ 1.m00608 423 KrLIHRDLKPANLLLKSsssKYpLLKIADYGFSRGI--DGMM-KSMVGTP 469 lPvkWmAPEslkygk.FtskSDVWSFGVlLWEiftlGeqPFYpgm.snee l APE ++ + ++t k D +S GV L+ + t P + +++++++ 1.m00608 470 L---YEAPE-IRKNQpYTAKADLYSLGVILYYMATKE-FP-FTDIpDVFQ 513 ..vlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFsel..vee + + + l + R ++ d l +l+l+ + +dR + +e+ ++ 1.m00608 514 naMTNEL-PAEFRDDIII--NDQLKHLILHLITHHEKDRLSWKEVykHPY 560 L<-* 1.m00608 561 V 561 Pkinase: domain 2 of 2, from 297 to 561: score 201.3, E = 2.3e-57 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y+ l++l G fG+V++a + + + +A+K+i+ r ++ 1.m00608 297 YKPLKQLDHGQFGQVFLAENTDHTQ-FAIKEISQRIDSLIR------ 336 lsEiqilkrLsHpNIvrlidvfed...............kdhlylVlEyc E++ ++ ++HpN v+++d+fe +++ + +++++++++++ylV+Eyc 1.m00608 337 --EASCMRLCKHPNLVEYKDFFEWnhsmiaeirgeqspeGKYVYLVMEYC 384 egGLrvldLfdylsetrrkgpllfsedeakkialQilrgleYLHs.ngii + G L y++ + +pl s +e+ ++ +i++gl YLH +++ i 1.m00608 385 NAG----NLEIYIK--NKPTPL--SNEEISYFLGEICSGLWYLHFnKRLI 426 HRDLKPeNILldnngvvdaflKiaDFGlAkklst.sss.lttfvGTpwYm HRDLKP+N+Ll++ + lKiaD G++ + ++ +++ vGTp Y 1.m00608 427 HRDLKPANLLLKSSSSKYPLLKIADYGFS----RgIDGmMKSMVGTPLYE 472 APEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirk APE+ + +++y+ k+D +SlGvily+++t+++PF d ++++ 1.m00608 473 APEIRK-NQPYTAKADLYSLGVILYYMATKEFPFT-------DIPDVFQN 514 ilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltae + +l+ ++ ++ i + +k+Li +++ ++Rl+++ 1.m00608 515 AMTNELPAEFRDDIIIN-----------DQLKHLILHLITHHEKDRLSWK 553 eilqHPwf<-* e+ +HP++ 1.m00608 554 EVYKHPYV 561 //